, 2006; Sawaya and Kraut, 1997; Figure 1—figure dietary supplement 1), we predicted the mutational landscape of DHFR to become constrained from the prerequisite to undertake these distinctive conformations. Moreover, prior get the job done had instructed DHFR is impacted by mobile constraints which include protein high quality Regulate (Bershtein et al., 2013) as well as the build-up of the harmful metabolic intermediate (Schober et al., 2019). We hence predicted deep mutational scanning to expose a very constrained mutational landscape for DHFR that would distinction Using the mutational tolerance noticed in other programs.

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The location of the DHFR gene is listed in parenthesis in the primary column. Expression values corresponds to the cell strain during the column heading.

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